Elucidating pathway arsenic methylation
A collaborative modeling project between epidemiologists, biologists, and mathematicians has the purpose of explaining existing data on methylation in human studies in Bangladesh and also testing, by mathematical modeling, effects of nutritional supplements that could increase As methylation.
We develop a whole body mathematical model of arsenic metabolism including arsenic absorption, storage, methylation, and excretion.
Due to the wide occurrence of arsenic (As) pollution in paddy soils and its efficient plant uptake, As in rice grains presents health risks.
Genetic manipulation may offer an effective approach to reduce As accumulation in rice grains.
The parameters for arsenic methylation in the liver were taken from the biochemical literature.
The transport parameters between compartments are largely unknown, so we adjust them so that the model accurately predicts the urine excretion rates of time for the i As, MMAs, and DMAs in single dose experiments on human subjects.
Objective: The objective of this study was to determine whether arsenic is associated with genomic hypomethylation of peripheral blood leukocyte (PBL) DNA in Bangladeshi adults who are chronically exposed to arsenic.
The installation of tube wells has been promoted in Bangladesh since the 1960s in an effort to reduce the high infant mortality due to waterborne microbial diseases contracted by drinking contaminated surface water (1).While in anaerobic environments like paddy soil, it mainly exists in the reduced form as arsenite (As III) (Huang et al., 2011). NIP1;1, an aquaporin homolog, determines the arsenite sensitivity of Arabidopsis thaliana. Compared to other cereals, rice is more efficient in accumulating As in its grains (Williams et al., 2007; Sohn, 2014). doi: 10.1016/j.scitotenv.20 Pub Med Abstract | Cross Ref Full Text | Google Scholar Kamiya, T., Tanaka, M., Mitani, N., Ma, J. Although biomethylation of arsenic has been studied for more than a century, unequivocal demonstration of the methylation of inorganic arsenic by humans occurred only about 30 years ago.
Because methylation of inorganic arsenic activates it to more reactive and toxic forms, elucidating the pathway for the methylation of this metalloid is a topic of considerable importance.
Understanding arsenic metabolism is of public health concern as millions of people chronically consume drinking water that contains high concentrations of inorganic arsenic.